B cells and complement at the forefront of chemotherapy
Nature Reviews Clinical Oncology, Published online: 05 May 2020; doi:10.1038/s41571-020-0376-0Effective anticancer therapies typically activate antitumour immunity, predominately mediated by T cells in the tumour microenvironment. Here, we discuss the roles of B cells and tertiary lymphoid structures in the context of chemotherapy-induced complement activation, which results in the induction of a B cell subset that modulates T cell function.
Source: Nature Reviews Clinical Oncology - Category: Cancer & Oncology Authors: Catherine Saut ès-Fridman Lubka T. Roumenina Source Type: research
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