B cells and complement at the forefront of chemotherapy

Nature Reviews Clinical Oncology, Published online: 05 May 2020; doi:10.1038/s41571-020-0376-0Effective anticancer therapies typically activate antitumour immunity, predominately mediated by T cells in the tumour microenvironment. Here, we discuss the roles of B cells and tertiary lymphoid structures in the context of chemotherapy-induced complement activation, which results in the induction of a B cell subset that modulates T cell function.
Source: Nature Reviews Clinical Oncology - Category: Cancer & Oncology Authors: Source Type: research