Deformable image registration uncertainty for inter-fractional dose accumulation of lung cancer proton therapy

With proton therapy, high target coverage can be achieved, while sparing dose to organs-at-risk (OARs) [1,2]. This makes it especially attractive for tumours with many surrounding OARs, such as cancers in the brain [3], skull base [4 –6], head and neck [7,8] or lung [9]. Recently, the potential of proton therapy has been assessed for non-small cell lung cancer (NSCLC) treatments [10–13], with the main concern being intra-fractional variability. To mitigate these effects, rescanning [14], gating [10], tracking [15] or 4D-opti misation [16,17] have all been investigated.

Source: Radiotherapy and Oncology - May 3, 2020 Category: Radiology Authors: Lena Nenoff, C ássia O. Ribeiro, Michael Matter, Luana Hafner, Mirjana Josipovic, Johannes A. Langendijk, Gitte F. Persson, Marc Walser, Damien Charles Weber, Antony John Lomax, Antje-Christin Knopf, Francesca Albertini, Ye Zhang Tags: Original Article Source Type: research