Whole-exome and RNA sequencing of pulmonary carcinoid reveals chromosomal rearrangements associated with recurrence

Neuroendocrine (NE) tumors of the lung comprise four distinct histologic types: typical carcinoid (TC), atypical carcinoid (AC), large cell neuroendocrine carcinoma (LCNEC), and small cell lung carcinoma (SCLC), as listed in the 2015 World Health Organization (WHO) classification of tumors of the lung, pleura, thymus and heart [1]. Although these four tumor types are grouped into the same category, PC (TC and AC) is not an early progenitor lesion of LCNEC or SCLC [2]. PC has distinct epidemiologic, clinical, histological, and genetic characteristics, and its incidence is not associated with cigarette smoking.

Source: Lung Cancer - May 3, 2020 Category: Cancer & Oncology Authors: Akihiko Miyanaga, Mari Masuda, Noriko Motoi, Koji Tsuta, Yuka Nakamura, Nobuhiko Nishijima, Shun-ichi Watanabe, Hisao Asamura, Akihiko Tsuchida, Masahiro Seike, Akihiko Gemma, Tesshi Yamada Source Type: research