Low-chloride- versus high-chloride-containing hypertonic solution for the treatment of subarachnoid hemorrhage –related complications: The ACETatE (A low ChloriE hyperTonic solution for brain Edema) randomized trial

ConclusionsOur pilot trial showed the feasibility and safety of replacing 23.4% NaCl infusions with 16.4% NaCl/Na-acetate infusions to treat cerebral edema in patients with SAH. The degree of hyperchloremia was similar in the two groups. 16.4% NaCl/Na-acetate infusions led to lower Cl− load and AKI rates than 23.4% NaCl infusions. Further multi-center studies are needed to corroborate these results.Trial registrationclinicaltrials.gov #NCT03204955, registered on 6/28/2017
Source: Journal of Intensive Care - Category: Intensive Care Source Type: research