Knee synovial fluid complement C3 ‐β chain levels correlate with clinical symptoms of knee osteoarthritis

ConclusionWe present first ‐hand evidence that the clinical symptoms of OA are mainly associated with C3 in the local SF rather than systemic circulation, suggesting local factors in the etiopathogenesis. Future local targeted therapies for pain management may be more effective and safer.

Source: International Journal of Rheumatic Diseases - April 13, 2020 Category: Rheumatology Authors: Tzu Hsuan Cheng, Seung Ho Yoon, Philip Lee, Dennis Dimaculangan, Aditya Vikram Maheshwari, Ming Zhang Tags: ORIGINAL ARTICLE Source Type: research