Elevated Circulating CD4 + CD25 + CD127 −/low Regulatory T Cells in Patients with Non-asthmatic Eosinophilic Bronchitis

This study aimed to preliminarily explore the role of Tregs in NAEB by comparing circulating Tregs levels to asthma and healthy controls.MethodsFractional exhaled nitric oxide (FeNO), spirometry with bronchial provocation test, sputum induction and blood routine test were performed in all subjects. Peripheral blood mononuclear cells were used to detect the Tregs (CD4+CD25+CD127−/low) by flow cytometry. Relationship between the levels of circulating Tregs and clinical indexes was also observed.ResultsA total of 15 patients with NAEB, 20 patients with asthma and 11 healthy controls were included. The absolute numbers of circulating Tregs in the NAEB group (49.8  ± 18.9 × 103 cells/ml) and asthma group (53.3  ± 18.7 × 103 cells/ml) were higher than that in healthy control group (32.7  ± 11.6 × 103 cells/ml) (bothP 
Source: Lung - Category: Respiratory Medicine Source Type: research

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AbstractIntroductionWhether non ‐asthmatic eosinophilic bronchitis (NAEB) shows response to bronchodilator (RB) remains unclear.ObjectivesTo investigate the RB and its relationship with clinical and pathophysiological features in NAEB.MethodsFifty ‐one patients with NAEB were assigned in a 2:1 ratio to receive oral bambuterol hydrochloride (n=34, 10mg, once daily, for 3 days) or matched placebo (n=17) randomly, of whom 48 patients (32 with bronchodilator and 16 with placebo) completed the study. Sputum induction, spirometry and cough reflex sensitivity were measured. RB was considered when cough VAS score decreased 30%...
Source: The Clinical Respiratory Journal - Category: Respiratory Medicine Authors: Tags: ORIGINAL ARTICLE Source Type: research
CONCLUSIONS: NAEB, CVA, and UACS are common causes of chronic cough in patients with AR. FeNO can first be used to discriminate patients with CVA/NAEB, then FEF25-75 (or combined with FeNO) can further discriminate patients with CVA from those with CVA/NAEB. PMID: 31552718 [PubMed]
Source: Allergy, Asthma and Immunology Research - Category: Allergy & Immunology Tags: Allergy Asthma Immunol Res Source Type: research
ier A Abstract Cough is divided into two categories: acute cough lasting less than 3 weeks, and chronic cough lasting more than 8 weeks. Acute cough is usually triggered by a viral infection of the upper airways. Evidence of treatment effectiveness is low and management of acute cough is complex in clinical practice. Chronic cough is a common reason for consultation in medicine. The most frequent causes are upper airway diseases, gastroesophageal reflux disease, asthma, eosinophilic bronchitis, and drugs. Before investigation, smoking cessation and drug withdrawal must be achieved for 4 to 6 weeks. Once this step ...
Source: Presse Medicale - Category: General Medicine Authors: Tags: Presse Med Source Type: research
We describe the overdiagnosis and the prevalence of spirometrically defined false positive COPD, as well as their relationship with overtreatment across 23 population samples in 20 countries participating in the BOLD Study between 2003-2012. METHODS: A false positive diagnosis of COPD was considered when participants reported a doctor's diagnosis of COPD, but post-bronchodilator spirometry was unobstructed (FEV1/FVC>LLN). Additional analyses were performed using the fixed ratio criterion (FEV1/FVC
Source: Chest - Category: Respiratory Medicine Authors: Tags: Chest Source Type: research
Conclusions: Disease severity: 73.7%(479) had at least 1 exacerbation/year, 28.2% received antibiotic treatment, 7% presented to the emergency room, 2.7% required hospitalization. The main reason behind screening spirometry is to provide the millions of people with the right treatment and spread awareness about it.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Monitoring Airway Disease Source Type: research
Introduction: Protracted bacterial bronchitis (PBB), the commonest cause of chronic cough in childhood, is characterised by chronic wet cough (>4 weeks duration) that usually responds to 2-wks of appropriate antibiotic therapy without evidence of an alternative cause for cough. There are no long term studies on PBB beyond 2 yrs.Objectives: Characterise the 5 yr outcomes for children with PBB.Methods: 151 children (median age 26-mo, range 4-163) requiring bronchoscopy (FB) were recruited (PBB=130, controls=21). Participants were followed up for 5 yrs (min 42 mo). Participants were monitored with monthly contact via resea...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Paediatric respiratory infection and immun. Source Type: research
ConclusionA careful observation of the flow/volume curve should always be guaranteed and the presence of congenital vascular anomalies should be suspected in case of difficult-to-treat asthma.
Source: Multidisciplinary Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Abstract RATIONALE: There are limited data on factors in young adulthood that predict future lung disease. OBJECTIVE: To determine the relationship between respiratory symptoms, loss of lung health, and incident respiratory disease in a population-based study of young adults. METHODS: Prospective data from 2749 participants in the Coronary Artery Risk Development in Young Adults (CARDIA) study who completed respiratory symptom questionnaires at baseline and 2 years later and repeated spirometry measurements over 30 years. MEASUREMENTS AND MAIN RESULTS: Cough or phlegm, episodes of bronchitis, wheeze...
Source: Am J Respir Crit Car... - Category: Intensive Care Authors: Tags: Am J Respir Crit Care Med Source Type: research
We studied the prevalence, burden and potential risk factors for chronic bronchitis symptoms in the Burden of Obstructive Lung Disease study. Representative population-based samples of adults aged ≥40 years were selected in participating sites. Participants completed questionnaires and spirometry. Chronic bronchitis symptoms were defined as chronic cough and phlegm on most days for ≥3 months each year for ≥2 years. Data from 24 855 subjects from 33 sites in 29 countries were analysed. There were significant differences in the prevalence of self-reported symptoms meeting our definition of chronic bro...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: COPD and smoking Original Articles: COPD Source Type: research
Abstract Although chronic cough in adults (cough lasting longer than eight weeks) can be caused by many etiologies, four conditions account for most cases: upper airway cough syndrome, gastroesophageal reflux disease/laryngopharyngeal reflux disease, asthma, and nonasthmatic eosinophilic bronchitis. Patients should be evaluated clinically (with spirometry, if indicated), and empiric treatment should be initiated. Other potential causes include angiotensin-converting enzyme inhibitor use, environmental triggers, tobacco use, chronic obstructive pulmonary disease, and obstructive sleep apnea. Chest radiography can r...
Source: American Family Physician - Category: Primary Care Authors: Tags: Am Fam Physician Source Type: research
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