[Epigenetics and pain.]

[Epigenetics and pain.] Anaesthesist. 2013 Dec 13; Authors: Niederberger E Abstract Chronic pain affects approximately 20 % of adults worldwide and is often associated with a decrease in the quality of life and various comorbidities. Conventional analgesic therapies are frequently insufficient and sometimes lead to severe side effects. Therefore, great efforts are still being made to elucidate the signalling pathways in pain and to develop new, safe and effective therapies. Epigenetic mechanisms which interfere with the regulation of gene expression are involved in the pathogenesis of several diseases and are gaining increasing impetus in medical research. As they are also involved in pain processing, a modulation of these mechanisms might represent a novel option for the therapy of pain patients. PMID: 24337072 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24337072?dopt=Abstract

Source: Der Anaesthesist - December 13, 2013 Category: Anesthesiology Authors: Niederberger E Tags: Anaesthesist Source Type: research