Antibacterial and antibiofilm activities of synthetic analogs of 3-alkylpyridine marine alkaloids

AbstractNowadays, the emergence of superbugs is one of the most serious public health problems. Strains ofStaphylococcus aureus andKlebsiella pneumoniae, resistant to many antimicrobials available in clinical practice, have become increasingly common. The development of new drugs for the treatment of infections caused by these pathogens is necessary and urgent. A series of 11 analogs of marine 3-alkylpyridine alkaloids was evaluated in vitro for its antibacterial potential. Compound6, a synthetic analog of viscosaline, exhibited significant activity againstS. aureus, including an MRSA strain (MIC  = 2 µg/mL). Additionally, it exhibited a 25% reduction in mature biofilm and a good selectivity index (SI >  16). None of the compounds exhibited activity againstK. pneumoniae, but analog6 was able to act in planktonic cells in the presence of polymyxin B at sub-inhibitory concentration. Compound6 has promising anti-staphylococcal activity and future assays are encouraged to investigate their therapeutic potential.
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research