Multiple Mechanisms Underlying the Long Duration of Action of Thienorphine, A Novel Partial Opioid Agonist for the Treatment of Addiction.

CONCLUSIONS: These results indicate that multiple factors, including persistent receptor occupation and enhanced receptor downregulation, may contribute to the long-lasting effects of thienorphine that would be beneficial for its application in addiction treatment. PMID: 24330593 [PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/24330593?dopt=Abstract

Source: CNS Neuroscience and Therapeutics - December 16, 2013 Category: Neuroscience Authors: Yu G, Li SH, Cui MX, Yan LD, Yong Z, Zhou PL, Su RB, Gong ZH Tags: CNS Neurosci Ther Source Type: research