Respiratory and haemodynamic perioperative adverse events in intravenous versus inhalational induction in paediatric anaesthesia: a systematic review and meta-analysis.

Respiratory and haemodynamic perioperative adverse events in intravenous versus inhalational induction in paediatric anaesthesia: a systematic review and meta-analysis. Paediatr Anaesth. 2020 May 01;: Authors: Blaauwendraad SM, Porter LL, Pieters BM Abstract Perioperative respiratory and haemodynamic adverse events are still a cause of morbidity and mortality in paediatric anaesthesia. It has been suggested that volatile agents might be associated with more respiratory adverse events compared to intravenous agents (e.g., propofol), which have been associated with a higher risk of bradycardia compared to volatile agents. We performed a systematic review and meta-analysis to evaluate the risk of perioperative haemodynamic and respiratory adverse events, comparing intravenous induction with inhalational induction in paediatric anaesthesia. We searched PubMed, Embase and Medline up to February 12th , 2020. Randomized controlled trials were included. A quality assessment was carried out using a modified version of the 'Cochrane Risk of Bias Tool for Randomized Controlled Trials.' Of the 1,602 applicable publications, four were included in the final review. Two studies found no significant differences in perioperative respiratory or haemodynamic adverse events. Two studies found a higher risk of respiratory perioperative adverse events in inhalation versus intravenous induction, with a relative risk varying from 1.64 to 3.83. Data was hete...
Source: Paediatric Anaesthesia - Category: Anesthesiology Authors: Tags: Paediatr Anaesth Source Type: research