Sean Sasser, One-Time Star of MTV's 'Real World,' Dies of Mesothelioma

Celebrity Sean Sasser of MTV fame lived productively for 25 years after being diagnosed with HIV, a testament to the progress that has been made in treating a once-deadly disease. Yet he lived only six weeks after being diagnosed with malignant mesothelioma, a reminder of how aggressive this asbestos cancer is. Sasser, who rose to fame in "The Real World: San Francisco," a reality television show that launched in the 1990s, died last week. He was 44. His death came soon after he was hit by the rare but lethal interaction of these two insidious diseases. "If you are HIV positive, and you get mesothelioma, it's going to travel like wildfire. It happens so fast, it makes your head spin," said Raja Flores, M.D., chief of thoracic surgery at Mount Sinai Hospital in New York City and a renowned authority on mesothelioma. "You hardly ever see it – I've seen it only twice in my life -- but you put the two together, and it's a real bad situation," Flores told Flores did not treat Sasser and did not speak of him specifically, but he responded to a question about the effect that HIV would have on a mesothelioma patient. Immune System Plays Key Role Mesothelioma, which is diagnosed in an estimated 3,000 Americans annually, is caused by inhalation or ingestion of microscopic asbestos fibers. There is normally a long latency period (10 to 50 years) between exposure and diagnosis. It is diagnosed typically in older patients (65-70) who worke...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Tags: Celebrities Source Type: news

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Publication date: 15 February 2021Source: Journal of Hazardous Materials, Volume 404, Part BAuthor(s): Yanhua Liu, Yang Li, Shanshan Dong, Lu Han, Ruixin Guo, Yourong Fu, Shenghu Zhang, Jianqiu Chen
Source: Journal of Hazardous Materials - Category: Environmental Health Source Type: research
Authors: Musio F Abstract INTRODUCTION: Anemia has and will continue to be a central theme in medicine particularly as clinicians are treating a burgeoning population of complex multi-organ system processes. As a result of multiple randomized controlled trials (RCTs), meta-analyses, and societal recommendations overly restrictive paradigms and under-administration of erythropoiesis stimulating agents (ESAs) have likely been followed by clinicians among all specialties. AREAS COVERED: A review of anemia in the context of chronic kidney disease, hematologic malignancies and cancer is presented with focus on the e...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Publication date: January 2021Source: Urology Case Reports, Volume 34Author(s): Nina Al-Saadi, Safa Al-Musawi, Yousuf Khan, Daben Dawam
Source: Urology Case Reports - Category: Urology & Nephrology Source Type: research
Authors: Matti B, Zargar-Shoshtari K Abstract Prostate cancer represents a significant health burden worldwide. The cancer incidence had substantially increased since the introduction of prostate specific antigen (PSA) in cancer screening. This had led to considerable debates among health professionals and epidemiologists, since PSA as a screening tool seemed to be far from perfect. In New Zealand, the controversy was quite prominent in the last three decades, with some advocating the benefits of screening, while others concerned regarding the risk of harms. With the absence of an organised screening programme and ...
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
CONCLUSION: This study found that childhood cancer survivors in New Zealand had a high prevalence of developmental dental abnormalities and it identified potential risk factors related to their cancer treatment. Inequitable access to oral rehabilitation for this patient group argues for a mechanism for consistent improved access to publicly funded dental care across district health boards in New Zealand. PMID: 33032302 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Conclusions: 68Ga-DATA-FAPi-05 is a promising PET tracer in the diagnosis of inconclusive results on 18F-FDG PET/CT. 68Ga-DATA-FAPi-05 is easy to prepare, labelled at room temperatures, which aids kit based preparations. It can be used as an alternative diagnostic option to 18F-FDG PET/CT. It is an ideal theranostic agent for the treatment of various cancers.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Dosimetry (Poster Session) Source Type: research
Conclusions This review describes how leukocyte-heparanase can be a double-edged sword in tumor progression; it can enhance tumor immune surveillance and tumor cell clearance, but also promote tumor survival and growth. We also discuss the potential of using heparanase in leukocyte therapies against tumors, and the effects of heparanase inhibitors on tumor progression and immunity. We are just beginning to understand the influence of heparanase on a pro/anti-tumor immune response, and there are still many questions to answer. How do the pro/anti-tumorigenic effects of heparanase differ across different cancer types? Does...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Conclusions Epidemiological studies have repeatedly helped identify definitive triggers for several diseases. As highlighted in this perspective report, previous studies strongly argue for the interplay between intrinsic factors and putative preventable extrinsic triggers/promoters for CTCL. Given the evidence of geographical regional clustering of CTCL patients, CTCL occurrence in unrelated family members and recent evidence implicating S. aureus in the pathogenesis/progression of CTCL, more research is needed to decipher the precise mechanism by which specific environmental exposures may be driving the pathogenesis of t...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Dr. Mags Portman, a British trailblazer in the fight to prevent and control HIV, died Wednesday after a two-year battle with mesothelioma. She was 44. Portman was lauded for triggering a significant reduction in HIV diagnoses throughout the United Kingdom by her work as a researcher, clinician and outspoken advocate. She earned international acclaim for her work as an HIV consultant at London’s Mortimer Market Centre, a progressive sexual health clinic that made pre-exposure prophylaxis (PrEP) a reality in the U.K. Portman played a key role in the 2014 study at The Royal London Hospital that proved the efficacy of t...
Source: Asbestos and Mesothelioma News - Category: Environmental Health Authors: Source Type: news
The separation of benign from malignant mesothelial proliferations is crucial to patient care, and subtyping of malignant mesotheliomas is important for selection of treatment options and estimating prognosis. These issues can present problems using routine morphology, and a variety of (sometimes controversial) markers have been proposed as aids.
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
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