Mechanical injury and IL-1 β regulated LOXs and MMP-1, 2, 3 expression in ACL fibroblasts co-cultured with synoviocytes.

CONCLUSIONS: SCs can either inhibit or increase LOX production in the presence of IL-1β, while promoting the accumulation of MMP in injured ACLfs. These results may provide crucial insights into the mechanisms underlying ACL poor healing capacity after injury.
PMID: 32358726 [PubMed - as supplied by publisher]

Source: Biotechnology Letters - April 30, 2020 Category: Biotechnology Authors: Wang C, Chi Q, Sha Y, Xu K, Xu C, Chen C, Huang W, Chen P, Chen P, Yang L, Sung KLP Tags: Biotechnol Lett Source Type: research