Peripheral clock system circadian abnormalities in Cushing's disease.

In conclusion, our data suggest that Cushing's disease, which is characterized by hypercortisolism, is associated with abnormalities in the circadian pattern of clock genes. Higher expression of CRY2 at night outlines its putative role in the cortisol circadian rhythm disruption.
PMID: 32354240 [PubMed - as supplied by publisher]

Source: Chronobiology International - April 29, 2020 Category: Biology Authors: Soares VR, Silva Martins C, Martinez EZ, Araujo LD, Roa SLR, Silva LR, Moreira AC, De Castro M Tags: Chronobiol Int Source Type: research