Changes in circulating microRNA and arterial stiffness following high ‐intensity interval and moderate intensity continuous exercise

We identified a reduction in central artery stiffness and an increase in carotid arterial compliance one hour after acute high intensity interval (HII) cycling exercise, that was not seen after moderate intensity continuous cycling (MOD). HII and MOD elicited distinct increases in the concentrations of circulating microRNAs (ci ‐miRs) with potential regulatory roles in arterial stiffness. Significant correlations between some of the changes in ci‐miRs and measures of arterial stiffness suggest potential mechanistic roles for ci‐miRs. AbstractHigh ‐intensity interval (HII) exercise elicits distinct vascular responses compared to a matched dose of moderate intensity continuous (MOD) exercise. However, the acute effects of HII compared to MOD exercise on arterial stiffness are incompletely understood. Circulating microRNAs (ci‐miRs) may con tribute to the vascular effects of exercise. We sought to determine exercise intensity‐dependent changes in ci‐miR potentially underlying changes in arterial stiffness. Ten young, healthy men underwent well‐matched, 30‐min HII and MOD exercise bouts. RT‐qPCR was used to determine the level s of seven vascular‐related ci‐miRs in serum obtained immediately before and after exercise. Arterial stiffness measures including carotid to femoral pulse wave velocity (cf‐PWV), carotid arterial compliance and β‐stiffness, and augmentation index (AIx and AIx75) were taken before, 10min af ter and 60min after exercise. Ci‐miR...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research