Early weaning augments the spontaneous release of dopamine in the amygdala but not the prefrontal cortex: an in vivo microdialysis study of male rats.

In this study, we investigated DAergic transmission in both these brain regions. The extracellular levels of amygdalar DA in adulthood were two times higher in rats weaned at 16 days compared to those weaned at 30 days in both the home cage and the open-field. This difference in extracellular DA levels was not apparent in the prefrontal cortex. The concurrently measured locomotor and rearing behaviors did not vary according to the weaning period and the probe-implanted region, respectively. These results suggest that the effects of early weaning on DA tone appear to be specific to the amygdala and do not represent ubiquitous upregulation as these changes were not observed in the prefrontal cortex.
PMID: 32350170 [PubMed - as supplied by publisher]

Source: Experimental Animals - May 2, 2020 Category: Research Tags: Exp Anim Source Type: research