The Endothelial Glycocalyx: A Fundamental Determinant of Vascular Permeability in Sepsis

Conclusions:
The endothelial glycocalyx is a fundamental component of the endothelium and an important determinant of the mechanotransduction and vascular permeability in patients with sepsis. Studies are needed to evaluate the role of the different types of solutions used in fluid bolus, vasoactive support, and other interventions described in pediatric sepsis on microcirculation, particularly on endothelial integrity and the glycocalyx.

Source: Pediatric Critical Care Medicine - May 1, 2020 Category: Pediatrics Tags: Online Review Articles Source Type: research