Nerve Growth Factor in Alcohol Use Disorders.
Nerve Growth Factor in Alcohol Use Disorders. Curr Neuropharmacol. 2020 Apr 28;: Authors: Ceci FM, Ferraguti G, Petrella C, Greco A, Ralli M, Iannitelli A, Carito V, Tirassa P, Chaldakov GN, Messina MP, Ceccanti M, Fiore M Abstract The nerve growth factor (NGF) belongs to the family of neurotrophic factors. Initially discovered as a signaling molecule involved in the survival, protection, differentiation and proliferation of sympathetic and peripheral sensory neurons, it also participates in the regulation of the immune system and endocrine system. NGF biological activity is due to the binding of two classes of receptors: the tropomyosin-related kinase A (TrkA), and the low-affinity NGF pan-neurotrophin receptor p75. Alcohol Use Disorders (AUD) are one of the most frequent mental disorders in developed countries, characterized by heavy drinking, despite the negative effects of alcohol on brain development and cognitive functions that cause individual's work, medical, legal, educational and social life problems. In addition, alcohol consumption during pregnancy disrupts the development of the fetal brain causing a wide range of neurobehavioral outcomes collectively known as fetal alcohol spectrum disorders (FASD). The rationale of this review is to describe crucial findings on the role of NGF in humans and animals when exposed to prenatal, chronic alcohol consumption and also on binge drinking. PMID: 32348226 [PubMed - as supplied by publisher]
INTRODUCTION: The use of tobacco, alcohol and other drugs usually starts during the adolescence. In Argentina, it happens at an increasingly younger age. The purpose of the study was to explore social and personal factors that can predict the start of cons...
CONCLUSION: A significant proportion of patients with LDL-C≥250 mg/dL were not taking lipid-lowering drugs. Similar with many other studies, diagnosis and treatment rates of FH patients were very low in our study. Further national studies are required to increase awareness of the disease in both physicians and patients. PMID: 32744105 [PubMed - as supplied by publisher]
Conclusions Drug and alcohol education strategies must be more explicit regarding harm across all drug types, regardless of legal status or perceived social acceptability. Prevention services would benefit from including lived realities from young people's varied, and changing, substance-use trajectories. Peer involvement in the design of preventive strategies (and involvement in participatory research to identify felt needs) is paramount to ensure teachings are grounded in a young person's social context and lived realities. So what? This study provides information to guide development of appropriate and authentic drug an...
Conclusions: In this cohort, racial/ethnic differences in sleep quality were common. PMID: 32742152 [PubMed - in process]
CONCLUSIONS: A higher risk of a negative outcome for mother and baby is seen among women born in Somalia compared to women born in Sweden. We suggest it may be worthwhile to investigate whether a Somali-adapted intervention with proactivity concerning self-monitoring of fetal movements may improve pregnancy outcomes in this migrant population. PMID: 32744184 [PubMed - in process]
CONCLUSION: The study helps to understand the views and perceptions of adolescents and key informants on gender equality and gender-based violence. Three main areas require more effort and greater investment to improve adolescent sexual and reproductive health: knowledge and use of contraceptives, gender inequality, and autonomy. There is poor knowledge of contraceptive methods, indicating a need to further integrate comprehensive sexual education, introduced in primary school, and to increase investment in training and monitoring teachers. PMID: 32741350 [PubMed - in process]
CONCLUSION: In the case of unintended or unwanted pregnancy, adolescents must also have adequate knowledge and access to safe abortion and associated counselling services. This study suggests a need to increase sexual and reproductive health literacy including information about safe abortion. This requires a holistic approach to sexual education and needs the support and involvement of adolescents themselves as well as parents, community members and healthcare workers. PMID: 32741348 [PubMed - in process]
Authors: Santisouk P, Hansana V, Thanh Huong N Abstract BACKGROUND: Pregnancy health literacy (PHL) among teenagers is considered a major protective factor for teenage pregnancy. In Lao PDR, 18% of girls aged 15-19 have begun childbearing and 15% of maternal deaths occur to teenage girls, particularly in rural areas. OBJECTIVE: The aim of this study was to describe PHL and its related factors among teenagers in Kaysone district. METHOD: This was a cross-sectional study conducted at Oudomvilay and Kheuakhaokat in Kaysone district in January 2019. The Teenage Pregnancy Health Literacy (TPHL) score was collect...
Publication date: Available online 3 August 2020Source: Pregnancy HypertensionAuthor(s): Xiaosong Yuan, Lingna Zhou, Bin Zhang, Huiyan Wang, Bin Yu, Jun Xu
(Reuters Health)—Age-adjusted hip fracture incidence has declined in the U.S. over the past four decades, aided by a decline in smoking and alcohol consumption, a new study suggests. Researchers examined data on 4,918 men and 5,634 women who participated in the prospective Framingham Heart Study from 1970 to 2010. Overall, the age-adjusted incidence of hip... [Read More]