Effect of curcumin nanoemulsions stabilized with modified phosphatidylcholine on skin carcinogenesis in transgenic mice K14E6.

Effect of curcumin nanoemulsions stabilized with modified phosphatidylcholine on skin carcinogenesis in transgenic mice K14E6. Curr Drug Metab. 2020 Apr 29;: Authors: Agame-Lagunes B, Alegria-Rivadeneyra M, Quintana-Castro R, Torres-Palacios C, Grube-Pagola P, Cano-Sarmiento C, Garcia-Varela R, Alexander-Aguilera A, García HS Abstract BACKGROUND: Cancer is one of the main causes of death by disease; several alternative treatments have been developed to counteract this condition. Curcumin (diferuloylmethane), extracted from the rhizome of Curcuma longa, has antioxidant, antiinflammatory, and anti-cancer properties; however, it has low water solubility and poor intestinal absorption. Carrier systems, such as nanoemulsions, can increase the bioavailability of lipophilic bioactive compounds. OBJECTIVE: To evaluate the effect of curcumin nanoemulsions prepared with lecithin modified with medium-chain fatty acids as an emulsifier, on the expression of the Cdk4, Ccne2, Casp8 and Cldn4 genes involved in the carcinogenesis process in K14E6 transgenic mice. METHODS: The emulsifier was prepared by interesterification of medium-chain fatty acids, pure lecithin, and immobilized phospholipase-1 on Duolite A568. An Ultraturrax homogenizer and a Branson Ultrasonic processor were used for the preparation of nano-emulsions, and a Zetasizer evaluated the particle size. qRT-PCR analysis was performed to quantify the cancer-related genes...
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research