Regulation of Circulatory Muscle-Specific MicroRNA during 8 km Run
Int J Sports Med DOI: 10.1055/a-1145-3595Acute prolonged endurance running has been shown to alter muscle-specific
circulating microRNA (miRNA) levels. Here, eighteen participants completed an 8
km run. We assessed the levels of hsa-miR-1–3p, -133a-3p, -133b, and
-206 and their correlation with conventional biomarkers following exercise.
Compared to before exercise (Pre), 8 km run significantly increased the
lactate level immediately after exercise (0 h). Myoglobin (Mb) level increased
at 0 h while creatine kinase (CK) level increased 24 h after exercise (24 h).
The levels of creatine kinase MB isoenzyme (CK-MB) and cardiac troponin I (cTnI)
were all elevated at 24 h and within the normal physiological range; The levels
of hsa-miR-1–3p, -133a-3p, -133b significantly increased at 0 h but only
hsa-miR-133a-3p still elevated at 24 h. Only hsa-miR-206 level decreased at 24
h; Additionally, the changes of hsa-miR-1–3p and hsa-miR-133a-3p were
correlated with Mb at 24 h. These findings suggest that muscle-specific miRNA
elevation in plasma is likely physiological and that these miRNA may be used as
potential biomarkers for load monitoring in individuals. [...] © Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents | Abstract | Full text
Source: International Journal of Sports Medicine - Category: Sports Medicine Authors: Yin, Xin Cui, Shufang Li, Xin Li, Wei Lu, Qiu ju Jiang, Xiao hong Wang, Hui Chen, Xi Ma, Ji zheng Tags: Physiology & Biochemistry Source Type: research