Adult-onset autoimmune diabetes in 2020: an update

Autoimmune diabetes is a polygenic multifactorial disorder characterized by the destruction of pancreatic beta cells, on an autoimmune basis, resulting in absolute insulin deficiency [1]. Type 1 diabetes (T1D) is the most aggressive form of autoimmune diabetes and, historically, has been largely considered a disorder of children and adolescents [2]. However, it has been recognized that an increasing number of new autoimmune diabetes cases occur during adulthood. While a small percentage of these cases have a clinical presentation similar to T1D, there is a substantial number of people with an initial clinical diagnosis of type 2 diabetes (T2D), but having detectable serum markers of beta-cell autoimmunity [3 –5].

Source: Maturitas - April 29, 2020 Category: Primary Care Authors: Ernesto Maddaloni, Chiara Moretti, Carmen Mignogna, Raffaella Buzzetti Source Type: research