What turns CREB on? And off? And why does it matter?

What turns CREB on? And off? And why does it matter? Cell Mol Life Sci. 2020 Apr 28;: Authors: Steven A, Friedrich M, Jank P, Heimer N, Budczies J, Denkert C, Seliger B Abstract Altered expression and function of the transcription factor cyclic AMP response-binding protein (CREB) has been identified to play an important role in cancer and is associated with the overall survival and therapy response of tumor patients. This review focuses on the expression and activation of CREB under physiologic conditions and in tumors of distinct origin as well as the underlying mechanisms of CREB regulation by diverse stimuli and inhibitors. In addition, the clinical relevance of CREB is summarized, including its use as a prognostic and/or predictive marker as well as a therapeutic target. PMID: 32347317 [PubMed - as supplied by publisher]
Source: Cellular and Molecular Life Sciences : CMLS - Category: Cytology Authors: Tags: Cell Mol Life Sci Source Type: research