Surfactant Injury in the Early Phase of Severe Meconium Aspiration Syndrome.

CONCLUSIONS: Various alterations of surfactant phospholipids and proteins were detected in the early phase of severe meconium aspiration, due to hydrolysis and inflammation and as a defensive response. This impairs both surfactant structure and function, finally resulting in a reduced lung aeration. These findings support the development of new surfactant protection and anti-inflammatory strategies for severe MAS. PMID: 32348683 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32348683?dopt=Abstract

Source: American Journal of Respiratory Cell and Molecular Biology - April 28, 2020 Category: Molecular Biology Authors: Autilio C, Echaide M, Shankar-Aguilera S, Bragado R, Amidani D, Salomone F, Pérez-Gil J, De Luca D Tags: Am J Respir Cell Mol Biol Source Type: research