The Effects of Vitamin D on Allergen-Induced Expression of Interleukin-13 and Interleukin-17 in Cord Blood CD4+T Cells.

The objective of our study was to investigate the effects of 1,25-(OH)2D3 on allergen-stimulated expression of asthma related cytokines in cord blood T cells. Cord blood samples were collected from the umblilical vein of 24 term deliveries during labor, CD4+T cells derived from cord blood mononuclear cells (CBMCs), were cultured for 72 hours with ovalbumin (OVA), β-lactoglobulin (β-LG), respectively, in presence or absence of 1,25-(OH)2D3 to detect the levels of interleukin-13 (IL-13) and interleukin-17 (IL-17) in culture supernatants and the mRNA expressions in CD4+T cells. After allergens stimulation, CD4+T cells showed an increase of IL-13 and IL-17 production, while cultured in the presence of 1,25-(OH)2D3 displayed a statistically significant down-regulation of allergen-induced expression of IL-13 and IL-17 in CD4+T cells. These results indicated that allergens may induce changes in CD4+T cell function to increase inflammatory cytokine production. 1,25-(OH)2D3 modulated the capacity of CD4+T cells in response to allergens, which might be protective for allergy. PMID: 24338253 [PubMed - in process]
Source: Iranian Journal of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Iran J Allergy Asthma Immunol Source Type: research