New Synthesized Galloyl ‐RGD Inhibits Melanogenesis by Regulating the CREB and ERK Signaling Pathway in B16F10 Melanoma Cells

In this study, we investigated the anti‐melanogenic effect of galloyl‐RGD and the underlying mechanism for this effect. Galloyl‐RGD markedly inhibited melanin content and tyrosinase activity in a concentration‐dependent manner. We also found that galloyl‐RGD decreased the levels of melanogenesis‐related gene and protein. In addition, galloyl‐RGD reduces intracellular cyclic adenosine monophosp hate (cAMP) levels that leads to inhibition of cAMP‐responsive element binding protein (CREB) phosphorylation and activates extracellular signal‐regulated kinase (ERK) expression. These results indicate that CREB and ERK regulation by galloyl‐RGD contributes to reduced melanin synthesis via de gradation of microphthalmia‐associated transcription factor (MITF). Therefore, galloyl‐RGD can be potential candidate for application in cosmetic or pharmaceutical industry.

Source: Photochemistry and Photobiology - April 28, 2020 Category: Science Authors: Seo Yeon Shin, Sang Ouk Sun, Jae Yeon Ko, Yun Seo OH, Seung ‐Sik Cho, Dae‐Hun Park, Kyung Mok Park Tags: RESEARCH ARTICLE Source Type: research