LINP1 Promotes the Progression of Cervical Cancer by Scaffolding EZH2, LSD1 and DNMT1 to Inhibit the Expression of KLF2 and PRSS8.
LINP1 Promotes the Progression of Cervical Cancer by Scaffolding EZH2, LSD1 and DNMT1 to Inhibit the Expression of KLF2 and PRSS8.
Biochem Cell Biol. 2020 Apr 29;:
Authors: Wu L, Gong Y, Yan T, Zhang H
Abstract
A growing body of evidence demonstrates that long non-coding RNAs (lncRNAs) are correlated with various cancers. LncRNA LINP1 has been proven as a key factor of malignant tumor development. However, it is still unclear about the role of LINP1 in cervical cancer (CC). In our research, a prominent increase of LINP1 was found in CC tissues in comparison with adjacent normal tissues. What's more, LINP1 expression was identified to be upregulated in CC cells compared with human cervical epithelial cell lines (HUCEC). Surprisingly, the downregulation of LINP1 markedly alleviated the proliferation and promoted the apoptosis of cells in CC. Besides, LINP1 significantly decreased CC tumor growth in vivo. Further, we observed LINP1 recruited EZH2, LSD1 and DNMT1 to reduce the expression of KLF2 and PRSS8. RT-qPCR showed silence of LINP1 elevated the expression of KLF2 and PRSS8 in CC cells. Loss-of-function assays disclosed upregulation of KLF2 and PRSS8 inhibited cell proliferation and boosted cell apoptosis in CC. Besides, inhibition of KLF2 and PRSS8 could reversed the inhibitory effect on cell proliferation resulted from LINP1 suppression. In short, LINP1 aggravated the progression of CC by suppressing KLF2 and PRSS8, which might pr...
Source: Biochemistry and Cell Biology - Category: Biochemistry Authors: Wu L, Gong Y, Yan T, Zhang H Tags: Biochem Cell Biol Source Type: research
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