Oxygenated xanthones as P-glycoprotein modulators at the intestinal barrier: in vitro and docking studies

In conclusion, the in vitro results confirmed OXs potential for P-gp induction and/or activation and suggested SW480 cells as a suitable in vitro model for these studies. However, P-gp activation did not protected SW480 cells against MTX cytotoxicity.In silico studies suggested the different binding locations as a limiting step in the P-gp-mediated efflux of its substrates under P-gp activation.

Source: Medicinal Chemistry Research - April 28, 2020 Category: Chemistry Source Type: research