Evaluation of OPAT in the Age of Antimicrobial Stewardship

AbstractPurpose of reviewAntimicrobial stewardship and outpatient parenteral antimicrobial therapy (OPAT) collide with the newest Joint Commission requirements for outpatient antimicrobial stewardship. The purpose of this paper was to present key stewardship areas applicable to OPAT and review the data behind them.Recent findingsData on these topics is emerging. Long treatment durations are being challenged and oral routes are garnering evidence for treatment of traditionally intravenous-only regimens. Stability information and incorporation of pharmacokinetic and pharmacodynamic properties may lead to use of continuous infusions, once daily dosing, or long-acting lipoglycopeptides. Different models for patient follow-up, frequency of monitoring, and adverse effect profiles can be used. As the popularity and necessity of OPAT and stewardship programs increase, there is opportunity for multidisciplinary collaboration.SummaryWhile there are many overlapping stewardship principles in OPAT, there may be appropriately discordant principles in this unique scenario as well.
Source: Current Treatment Options in Infectious Diseases - Category: Infectious Diseases Source Type: research