Issue Cover (May 2020)

Front cover:Ocular microvasculopathies compromise vision in diseases as retinopathy of prematurity and proliferative diabetic retinopathy. Using the oxygen induced retinopathy mouse model, we investigated the effects of aflibercept in modulating the aberrant retinal microvascular response to ischemia.Image content: In this image, a magnified view of a retina from a mouse subjected to the oxygen ‐induced retinopathy protocol and subsequently treated with aflibercept is shown. The tissue was immunolabeled with antibodies against the neural/glial antigen 2 (NG2, red) and the glial fibrillary acidic protein (GFAP, green), widely‐used markers of pericytes and astrocytes, and imaged at the d epth of the retinal superficial vascular plexus. The immunoreactivity of neovascular tufts to both NG2 and GFAP suggests an unclear identity of the cells forming them (DAPI, blue). Aflibercept remarkably reduces the extent of neovascularization and protects dopaminergic amacrine cells against hypoxi a, ultimately leading to enhanced light sensitivity in this model as assessed by electroretinography.Read the full article ‘VEGF‐Trap is a potent modulator of vasoregenerative responses and protects dopaminergic amacrine network integrity in degenerative ischemic neovascular retinopathyy’ by J. E. Rojo Arias, M. Economopoulou, D. A. Ju árez López, A, Kurzbach, K. H. Au Yeung, V. Englmaier, M. Merdausl, M. Schaarschmidt, M. Ader, H. Morawietz, R. H. W. Funk, J. Jászai, (J. Neurochem. 20...
Source: Journal of Neurochemistry - Category: Neuroscience Tags: Issue Cover Source Type: research