Targeting the 4-1BB costimulatory molecule through single chain antibodies promotes the human T-cell response.

Conclusions: Our results demonstrate that targeting the 4-1BB molecule using agonistic scFvs could be an effective strategy for T-cell stimulation as part of an ACT approach to cancer treatment. PMID: 32336974 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32336974?dopt=Abstract

Source: Cellular and Molecular Biology Letters - April 29, 2020 Category: Biochemistry Authors: Bagheri S, Safaie Qamsari E, Yousefi M, Riazi-Rad F, Sharifzadeh Z Tags: Cell Mol Biol Lett Source Type: research