The key role of Akt protein kinase in metabolic-inflammatory pathways cross-talk: TNF- α down-regulation and improving of insulin resistance in HepG2 cell line.

CONCLUSIONS: The obtained data demonstrated that TNF-α protein expression reduction improved insulin-stimulated Akt phosphorylation in the HepG2 cells and decreased lipid-induced insulin resistance of the diabetic hepatocytes. PMID: 32338219 [PubMed - as supplied by publisher]
Source: Current Molecular Medicine - Category: Molecular Biology Authors: Tags: Curr Mol Med Source Type: research