Single cell transcriptome in chronic myeloid leukemia (cml): pseudotime analysis reveals evidence of embryonic and transitional stem cell states

Chronic myeloid leukemia is a clonal hematopoietic malignancy, characterized by the acquisition of the t (9;22) translocation leading to Ph1 chromosome and its counterpart BCR-ABL oncogene, in a very primitive hematopoietic stem cell (Houshmand M et al, 2019). CML is a model of targeted therapies as the proof of concept of the feasibility of targeting the tyrosine kinase (TK) activity BCR-ABL using TK inhibitors (TKI) has been shown to lead to major responses and remissions(Deininger et al., 2009) .

Source: Experimental Hematology - April 27, 2020 Category: Hematology Authors: S. Pagliaro, C. Desterke, H. Acloque, J.C. Chomel, L de Souza, P. Hugues, F. Griscelli, A. Foudi, A. Bennaceur-Griscelli, A.G. Turhan Source Type: research