Dysmetabolic iron overload syndrome and its relationship with HFE gene mutations and with liver steatosis

The dysmetabolic iron overload syndrome (DIOS) is characterized by producing hyperferritinemia (HF) with slight elevation of the hepatic iron concentration, usually a normal transferrin saturation (TS), together with one or more diagnostic factors of metabolic syndrome (MtS) [1,2]: obesity, arterial hypertension, dyslipidaemia, and/or abnormal metabolism of glucose or BMI> 25  kg/m². It is associated up to 50% with NAFLD / NASH [3]. The diagnosis is made discarding the usual causes of hepatic iron overload (hereditary hemochromatosis, alcohol, secondary hemosiderosis, etc.).

Source: Digestive and Liver Disease - April 27, 2020 Category: Gastroenterology Authors: Agust ín Castiella, Iratxe Urreta, Eva Zapata, MªDolores de Juan, José Mª Alústiza, José Ignacio Emparanza, Burnia Group Tags: Correspondence Source Type: research