Response of thyrotropin-secreting pituitary tumors to preoperative lanreotide therapy. Report of two cases.

Response of thyrotropin-secreting pituitary tumors to preoperative lanreotide therapy. Report of two cases. Neuro Endocrinol Lett. 2020 Apr 27;41(1) Authors: Tokutsu A, Okada Y, Torimoto K, Otsuka T, Narisawa M, Kurozumi A, Tanaka Y Abstract Case 1 was a 51-year-old man diagnosed with thyrotropin (TSH)-secreting pituitary tumor. The octreotide loading test showed suppression of TSH secretion. Treatment with lanreotide preoperatively at 90 mg/month resulted in normalization of thyroid function. Three months after treatment initiation, tumor shrinkage was observed, and pituitary tumor resection was performed through transsphenoidal surgery. Case 2 was a 47-year-old woman in whom the octreotide loading test showed suppressed TSH secretion. Treatment with lanreotide preoperatively at 90 mg/month resulted in normalization of thyroid function. After six months of treatment, tumor reduction was observed, and transsphenoidal surgery was performed. In both cases, lanreotide administration before TSH-secreting pituitary tumor resection achieved normalization of thyroid function and tumor shrinkage. Treatment with lanreotide seems effective in patients who show TSH secretion suppression in the octreotide loading test. PMID: 32338854 [PubMed - as supplied by publisher]
Source: Neuroendocrinology Letters - Category: Endocrinology Tags: Neuro Endocrinol Lett Source Type: research