Noninvasive hippocampal blood-brain barrier opening in Alzheimer’s disease with focused ultrasound [Neuroscience]

The blood–brain barrier (BBB) presents a significant challenge for treating brain disorders. The hippocampus is a key target for novel therapeutics, playing an important role in Alzheimer’s disease (AD), epilepsy, and depression. Preclinical studies have shown that magnetic resonance (MR)-guided low-intensity focused ultrasound (FUS) can reversibly open the BBB and...

Source: Proceedings of the National Academy of Sciences - April 27, 2020 Category: Science Authors: Ali R. Rezai, Manish Ranȷan, Pierre–Francois D’Haese, Marc W. Haut, Jeffrey Carpenter, Umer Naȷib, Rashi I. Mehta, J. Levi Chazen, Zion Zibly, Jennifer R. Yates, Sally L. Hodder, Michael Kaplitt Tags: Brief Reports Biological Sciences Source Type: research