Widespread and tissue-specific expression of endogenous retroelements in human somatic tissues

ConclusionsThis study shows that ERE expression in somatic tissues is more pervasive and heterogeneous than anticipated. The high and diversified expression of EREs in mTECs and their ability to generate MAPs suggest that EREs may play an important role in the establishment of self-tolerance. The viral-like properties of ERE-derived MAPs suggest that those not expressed in mTECs can be highly immunogenic.
Source: Genome Medicine - Category: Genetics & Stem Cells Source Type: research