Recombinant Prefusion Measles and Mumps F and F –HN (H) Glycoproteins for Vaccine Development

The Measles virus (MeV) and Mumps virus (MuV) are highly contagious paramyxoviruses that can be transmitted by respiratory droplets from or on direct contact with an infected person. The resulting diseases can lead to serious complications or death among children. The existing vaccines for MeV and MuV are live attenuated virus vaccines which are administered in two subcutaneous doses at 1 year of age and as early as one month later. Two doses of a combination measles, mumps and rubella vaccine are 97% effective against measles and 88% against mumps. A single dose of a combination measles, mumps, and rubella vaccine is 93% effective against measles and 78% effective against mumps.Despite the effectiveness of the current licensed vaccines against MeV and MuV, incidences of both have increased in recent years. Contributing factors include reduced vaccination rates (especially in the U.S) due to vaccine hesitancy and circulation of divergent strains against which the licensed MMR vaccine offers limited protection. In the case of MuV, recent studies have shown that immunity wanes significantly after the second MMR vaccination which normally occurs in childhood. In response to recent recurring MuV disease outbreaks in the U.S and Europe, the Advisory Committee on Immunization Practices is advising a third MMR vaccination to boost protection. However, existing immunity neutralizes a third MMR vaccination limiting its effectiveness. Genotype G MuV is the main cause of recent outbreak...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research

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CONCLUSION: We identified three clusters with different healthcare beliefs and distinct sociodemographics. PMID: 32934130 [PubMed - as supplied by publisher]
Source: Journal of Rheumatology - Category: Rheumatology Tags: J Rheumatol Source Type: research
56% of Republicans said definitely or probably would not get vaccinated.
Source: Forbes.com Healthcare News - Category: Pharmaceuticals Authors: Tags: Business /business Innovation /innovation Science /science Healthcare /healthcare Breaking breaking-news Coronavirus SportsMoney Source Type: news
(CNN) — There have been 971 cases of measles reported in the United States this year, the US Centers for Disease Control and Prevention said Thursday. This means 2019, which is not quite half over, now has the greatest number of cases in a single year in nearly three decades. The number of cases in 1994 was 963, which was lower than in 1992 when there were 2,237 cases. “Measles is preventable and the way to end this outbreak is to ensure that all children and adults who can get vaccinated, do get vaccinated. Again, I want to reassure parents that vaccines are safe, they do not cause autism. The greater danger i...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - Category: Consumer Health News Authors: Tags: Health News CNN Measles Source Type: news
Unvaccinated individuals have been the focus of attention during this year’s measles outbreaks. A record 704 cases of the illness have been confirmed in 22 states so far in 2019, and the CDC says the majority of those diagnoses have been in unvaccinated people. Health officials have repeatedly warned nearly everyone to get the shot if they haven’t already — sometimes threatening fines for those who refuse. “Over 90% of the measles cases that have occurred in the U.S. have occurred in unvaccinated persons,” says Dr. William Schaffner, a professor of preventive medicine and infectious diseases a...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized public health Source Type: news
The Ohio teenager who made headlines for getting vaccinated against his mother’s wishes told the Senate on Tuesday that spreading vaccine misinformation is dangerous — but urged the public not to vilify those who do so. “Approaching this issue with the concern of education and addressing misinformation properly can cause change, as it did for me,” 18-year-old Ethan Lindenberger said while testifying before the Senate Health, Education, Labor and Pensions Committee on Tuesday. “Although the debate around vaccines is not necessarily centered around information, and concerns for health and sa...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime onetime vaccines Source Type: news
With the introduction of measles-mumps-rubella (MMR) vaccination, the mumps incidence decreased dramatically.1 Mumps vaccination has been assumed to provide lifelong immune protection, as seems to be the case after natural infection. However, several countries reported mumps outbreaks among vaccinated young adults, indicating less long-lived protection than anticipated.1,2 Waning of anti-MuV antibody levels has been attributed to the resurgence of mumps,3,4 but failing of cellular immune responses may be occurring as well.
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: Letter to the Editor Source Type: research
This piece comes to us courtesy of EdSource, where it was originally published. Mississippi hasn’t had a case of measles since 1992. West Virginia last saw measles – a highly contagious virus that kills an estimated 314 people worldwide every day – in 2009. Now, with California’s new vaccination law rolling out shot by shot, the state joins Mississippi and West Virginia to become the third in the nation to adopt stringent vaccination school entrance requirements. And medical experts say disease rates are likely to fall in California as they have in those states. “It’s a good club to...
Source: Healthy Living - The Huffington Post - Category: Consumer Health News Source Type: news
Conclusion We leave you with words from Robin: “My family and I hope that Holly’s story will make a difference and help you realize that you must be aware of the risks of vaccinations, just as you make yourself aware of the risks of any medical procedure. We hope to make change, and one very important improvement must be that the pediatricians acknowledge that there are vaccine reactions, that moderate to serious and even fatal vaccine reactions do exist and occur at least 100 times more than is reported to the Vaccine Adverse Event Reporting System (VAERS).  We are still very disappointed and disgusted wi...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Augustina Ursino Human Top Stories adverse reactions Holly Marie Stavola Holly's Law MMR vaccine National Vaccine Injury Compensation Program (NVICP) Robin Stavola truth about vaccines Vaccine Death VAERS Source Type: blogs
Commentary on: Tubeuf S, Edlin R, Shourie S, et al. Cost effectiveness of a web-based decision aid for parents deciding about MMR vaccination: a three-arm cluster randomized controlled trial in primary care. Br J Gen Pract 2014;64:e493–9. Implications for practice and research Decision aids can help inform parents about vaccine decisions for their children, which is critical in an age of vaccine hesitancy and refusal. Web-based decision aids may be a low-cost or free means of helping parents to understand the measles, mumps, and rubella (MMR) vaccination, supplementing information they receive from healthcare provide...
Source: Evidence-Based Nursing - Category: Nursing Authors: Tags: Health policy, General practice / family medicine, Child health, Immunology (including allergy), Drugs: infectious diseases, Vaccination / immunisation, Child health, Health service research Source Type: research
Conclusion Will Governor Jerry Brown think twice and really risk the wrath of the black community? Will he even read Mrs. Sullivan’s letter or care about the many religious groups opposing vaccinations due to their ingredients? It appears that more governments worldwide are mandating vaccinations on a daily basis and parents are completely powerless to stop them. Who are these people who make all the decisions, and what right do they have to impose their largely unproven theories that ALL vaccinations are safe and effective for ALL children? Let’s face it, it does make you wonder what their real agenda is, does...
Source: vactruth.com - Category: Allergy & Immunology Authors: Tags: Christina England Logical Top Picks Mandatory Vaccination SB 277 vaccine mandate Source Type: blogs
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