From ‘COVID Toes’ to Hives, These Are the Skin Conditions Dermatologists Think Could Be Signs of Coronavirus

Dermatologists around the world are gathering data on what may be largely overlooked symptoms of COVID-19: skin conditions ranging from rashes to “pseudo-frostbite.” Many viral illnesses—including chickenpox, measles and mononucleosis—are accompanied by telltale skin rashes, often a result of the body’s heightened inflammatory response while fighting off infection. Though more research is needed, a growing number of case reports and preliminary studies suggest SARS-CoV-2, the virus that causes COVID-19, can also affect the skin. In late March, an Italian physician submitted a letter to the editor of the Journal of the European Academy of Dermatology and Venereology, describing skin conditions that affected about 20% of 88 COVID-19 patients analyzed in the Lombardy region of Italy. Most of them developed a red rash on their torsos, while a few suffered hives or blisters resembling chickenpox. Then, in early April, a dermatology organization representing more than 400 French dermatologists issued a statement noting that among probable COVID-19 patients they had seen skin symptoms including hives, red rashes and frostbite-like lesions on the extremities. And finally, in mid-April, in a letter to the editor of the Journal of the American Academy of Dermatology, a group of Italian physicians described a chickenpox-like rash as “a rare but specific COVID-19-associated skin manifestation.” In the U.S., the “pseudo-frostbite” co...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 UnitedWeRise20Disaster Source Type: news

Related Links:

Conclusions: Results from a head-to-head study showed that, compared with secukinumab, guselkumab had lower NNTs and CPRs for PASI 75, PASI 90, and PASI 100 responses. PMID: 32479140 [PubMed - as supplied by publisher]
Source: Journal of Dermatological Treatment - Category: Dermatology Tags: J Dermatolog Treat Source Type: research
Authors: Barber MRW, Clarke AE Abstract INTRODUCTION: Systemic lupus erythematosus (SLE) is an autoimmune disorder that affects almost every organ system and it is treated with immunomodulation and immunosuppression. SLE patients have an intrinsically dysfunctional immune system which is exacerbated by disease activity and leaves them vulnerable to infection. Treatment with immunosuppression increases susceptibility to infection, while hydroxychloroquine use decreases this risk. Infectious diseases are a leading cause of hospitalization and death. AREAS COVERED: This narrative review provides an overview of rec...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
Authors: Megna M, Cinelli E, Camela E, Fabbrocini G Abstract INTRODUCTION: Psoriasis is a very common chronic inflammatory skin disease affecting up to 3% of the general population with 75% of the psoriasis subjects being affected by a mild form of disease. Hence, topical therapy is the most frequent employed treatment in psoriasis also because it can be easily combined with systemic therapy. In this context, calcipotriol/betamethasone dipropionate (Cal/BD) fixed-dose association represents the first-line treatment due to its efficacy and once-daily application. Different Cal/BD formulations, such as ointment, gel ...
Source: Expert Review of Clinical Immunology - Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research
In this study, we reported clinical, immunologic, and genetic evaluation of two Iranian patients from unrelated families, both suffering from recurrent respiratory tract infections, failure to thrive, interstitial lung disease, autoimmune cytopenia, and hypogammaglobulinemia. Pulmonary abscess in one patient and persistent enteropathy in another were also observed. Further investigations revealed causative mutations in the exon (c.2166_2766del) and intron (c.4730-3 T > G) of the LRBA gene. These results may provide further elucidation of the clinical phenotypes and responsible genetic factors of LRBA defi...
Source: Immunological Investigations - Category: Allergy & Immunology Tags: Immunol Invest Source Type: research
T follicular helper (Tfh) cells are indispensable for the formation of germinal center (GC) reactions, whereas T follicular regulatory (Tfr) cells inhibit Tfh-mediated GC responses. Aberrant activation of Tfh cells contributes substantially to the pathogenesis of autoimmune diseases, such as systemic lupus erythematosus (SLE). Nonetheless, the molecular mechanisms mitigating excessive Tfh cell differentiation are not fully understood. Herein we demonstrate that the adenovirus E4 promoter-binding protein (E4BP4) mediates a feedback loop and acts as a transcriptional brake to inhibit Tfh cell differentiation. Furthermore, we...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Allergic asthma is mediated by Th2 responses to inhaled allergens. Although previous experiments indicated that Notch signaling activates expression of the key Th2 transcription factor Gata3, it remains controversial how Notch promotes allergic airway inflammation. Here we show that T cell–specific Notch deficiency in mice prevented house dust mite–driven eosinophilic airway inflammation and significantly reduced Th2 cytokine production, serum IgE levels, and airway hyperreactivity. However, transgenic Gata3 overexpression in Notch-deficient T cells only partially rescued this phenotype. We found that Notch sig...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Cases in Africa pass 150,000; Germany eases travel ban;Wuhan doctor who worked with whistleblower diesGermany lifts travel warning for EuropeChina withheld data on coronavirus from WHO, recordings reveal‘We can’t relax’: Europeans face up to life after lockdownUK coronavirus updates – liveCoronavirus latest: at a glance9.00pmBSTKey developments in the globalcoronavirus outbreak today include:8.52pmBSTThe USA has confirmed 14,790 more cases and 761 more deaths in the past 24 hours, according to the Centers for Disease Control and Prevention (CDC). That takes the cumulative totals to 1,802,470 and 105...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak World news Infectious diseases Science Microbiology Medical research UK news US news Australia news Source Type: news
Athletes who test positive for SARS-CoV-2, the virus that causes COVID-19, should take at least two weeks off from intense or competitive exercise and even more if they show signs of myocarditis, according to two new reports.Reuters Health Information
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Infectious Diseases News Source Type: news
Infants with symptomatic COVID-19 infection harbor higher SARS-CoV-2 viral loads in the nose at presentation but develop less severe disease as compared to older children and adolescents, report clinicians from New York City.Reuters Health Information
Source: Medscape Critical Care Headlines - Category: Intensive Care Tags: Pediatrics News Source Type: news
Authors: Alanagreh L, Alzoughool F, Atoum M Abstract The emerging COVID-19 pandemic poses a threat to the global health care system. Given the lack of antiviral therapies or vaccines for the disease, the antimalarial drug hydroxychloroquine (HCQ) obtained much attention as a treatment for COVID-19. However, there are limited and uncertain clinical data to support the beneficial effect of this drug in COVID-19 treatment. HCQ has several side effects and warnings, including blindness, heart failure, and renal toxicity, even with recommended doses. For severe cases of COVID-19 or in patients with preexisting condition...
Source: International Journal of Risk and Safety in Medicine - Category: Drugs & Pharmacology Tags: Int J Risk Saf Med Source Type: research
More News: Academies | Asthma | Autoimmune Disease | Chickenpox | Coronavirus | COVID-19 | Dermatology | Eczema | France Health | Glandular Fever (infectious mononucleosis) | Health | Hives | Italy Health | Itchiness | Learning | Liver | Measles | Psoriasis | SARS | Skin | Study | Universities & Medical Training | Urology & Nephrology