Health Outcomes With Vitamin D Supplementation —Reply

In Reply Our Editorial accompanied the report of the VITAL-DKD trial. The focus of that article and our Editorial was the lack of benefit of vitamin D supplementation over placebo for prevention of chronic kidney disease end points. We concluded that the VITAL-DKD and D2d trials “provide strong clinical trial–grade evidence against … kidney-protective effects of routine vitamin D3 supplementation in the vast majority of patients with prediabetes or established type 2 diabetes,” and emphasized the discrepancy between the “negative” results of these trials relativ e to previous observational studies that suggested benefits of higher vitamin D levels.
Source: JAMA - Category: General Medicine Source Type: research