Correlation between breath ammonia and blood urea nitrogen levels in chronic kidney disease and dialysis patients

Previous studies have shown that breath ammonia (breath-NH 3 ) concentration is associated with blood urea nitrogen (BUN) levels. However, interindividual variations in breath-NH 3 concentrations were observed. Thus, the present study aimed to assess the effect of oral cavity conditions on breath-NH 3 concentration and to validate whether the measurement of breath-NH 3 concentration is feasible in clinical settings. A total of 125 individuals, including patients with stage 3 to 5 chronic kidney disease (CKD3 –5), those on dialysis, and healthy participants, were recruited. A nanostructured sensor was used to detect breath-NH 3 concentrations. Pre- and post-gargling as well as pre- and post-hemodialysis (HD) breath-NH 3 , salivary pH, and salivary urea levels were measured. Breath-NH 3 , salivary urea, salivary pH, and BUN levels were positively correlated to each other. Breath-NH 3 concentrations were as...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Source Type: research