Correlation between breath ammonia and blood urea nitrogen levels in chronic kidney disease and dialysis patients
Previous studies have shown that breath ammonia (breath-NH 3 ) concentration is associated with
blood urea nitrogen (BUN) levels. However, interindividual variations in breath-NH 3 concentrations
were observed. Thus, the present study aimed to assess the effect of oral cavity conditions on
breath-NH 3 concentration and to validate whether the measurement of breath-NH 3 concentration is
feasible in clinical settings. A total of 125 individuals, including patients with stage 3 to 5
chronic kidney disease (CKD3 –5), those on dialysis, and healthy participants, were recruited. A
nanostructured sensor was used to detect breath-NH 3 concentrations. Pre- and post-gargling as well
as pre- and post-hemodialysis (HD) breath-NH 3 , salivary pH, and salivary urea levels were
measured. Breath-NH 3 , salivary urea, salivary pH, and BUN levels were positively correlated to
each other. Breath-NH 3 concentrations were as...
Source: Journal of Breath Research - Category: Respiratory Medicine Authors: Chang-Chiang Chen, Ju-Chun Hsieh, Cheng-Han Chao, Wei-Shun Yang, Hui-Teng Cheng, Chieh-Kai Chan, Chia-Jung Lu, Hsin-Fei Meng and Hsiao-Wen Zan Source Type: research
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