Hereditary Ataxias in Cuba: Results and Impact of a Comprehensive, Multidisciplinary Project.

Hereditary Ataxias in Cuba: Results and Impact of a Comprehensive, Multidisciplinary Project. MEDICC Rev. 2019 Oct;21(4):39-45 Authors: Rodríguez-Labrada R, Medrano-Montero J, Velázquez-Pérez L Abstract Spinocerebellar ataxia type 2 is a degenerative disease that causes physical disability and, ultimately, prostration and death. Globally, reported prevalence is around 3 cases per 100,000 population and Cuba has the world's highest rates of the disease, affecting both patients and their at-risk descendants. In Holguín Province, which has the country's highest concentration of cases, incidence is 4.4 per 100,000 population and prevalence is 40.2 per 100,000 population. In 2000, a specialized research center was established in that province. Supplied with the necessary equipment and human resources, the center conducted national multidisciplinary studies involving molecular biology, clinical care, epidemiology, psychology, clinical neurophysiology, imaging, clinical genetics and community medicine, among others. A training and continuing education program also raised scientific capacity. Priority was given to developing international collaborations for academic exchange and training of Cuban researchers.Multiple results from research involving clinical and epidemiologic characterization of the disease, identification of biomarkers and therapeutic targets, genetic association studies, clinical trials and characterization of the disea...
Source: MEDICC Review - Category: International Medicine & Public Health Tags: MEDICC Rev Source Type: research