Drug-Delivery Patch Shows Promise for an Overlooked Disease

A biodegradable drug-delivery patch met the primary and multiple secondary endpoints in a phase 2b study in patients with oral lichen planus (OLP), a chronic inflammatory condition characterized by lesions and ulcers inside the mouth. According to AFYX Therapeutics, the study is the largest randomized, double-blind, placebo-controlled study ever conducted in OLP patients. The 20 μg dose Rivelin clobetasol patch (Rivelin-CLO) demonstrated a statistically significant improvement in ulcer area, and continued to show improvement through the end of four weeks, the Copenhagen, Denmark-based company said. Secondary endpoints focused on capturing patient symptomatic improvement also demonstrated statistical significance, AFYX said. The company also noted that no serious adverse events were observed and patients reported overall ease of use and patch adherence to the oral cavity for an average of 90 minutes. The study was conducted in Europe and North America, "We are excited by the results of this phase 2b study of Rivelin-CLO, which clearly demonstrated first-of-its kind therapeutic benefit for patients with OLP, a condition for which no approved therapies exist," said Nishan de Silva, MD, CEO of AFYX Therapeutics. "Investigators we have been working with have expressed challenges with existing treatment options – topical treatments, ointments, and mouth rinses that don't provide adequate results&Acir...
Source: MDDI - Category: Medical Devices Authors: Tags: R & D Source Type: news

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Graft-versus-host disease (GvHD) represents a leading cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (allo-HCT).4-6 GvHD can lead to a high symptomatic burden, decline in functional status and poor quality of life.7,8 Cutaneous GvHD occurs frequently and is the most common presenting sign, highlighting the importance of early dermatologic diagnosis and intervention to mitigate disease progression.9 Acute GvHD (aGvHD) typically presents with a maculopapular rash whereas chronic GvHD (cGvHD) presents with poikiloderma, lichen planus-like, lichen sclerosus-like, morphea-like, and sclerotic features.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
CONCLUSION: K17 is potentially expressed in certain inflammatory skin diseases, including psoriasis and lichen planus. Besides, it is not always a marker of hyperproliferation of keratinocytes in skin diseases.PMID:34552343 | PMC:PMC8450673 | DOI:10.2147/CCID.S322226
Source: Clinical, Cosmetic and Investigational Dermatology - Category: Dermatology Authors: Source Type: research
CONCLUSIONS: The specific concentrations of cortisol, estrogen, and nicotine as stressors can effectively reduce the expression of HSP70 in normal oral mucosal keratinocytes. These phenomena can be effective in cell viability and the development of oral lichen planus.PMID:34545710 | DOI:10.1002/cre2.493
Source: Cell Research - Category: Cytology Authors: Source Type: research
Source: Journal of the American Academy of Dermatology - Category: Dermatology Authors: Source Type: research
CONCLUSION: We describe a form of facial lichen planus that is highly particular in terms of its follicular tropism, its blaschkoid distribution, its pigmented character, and its atrophic progression.PMID:34538651 | DOI:10.1016/j.annder.2021.08.003
Source: Annales de Dermatologie et de Venereologie - Category: Dermatology Authors: Source Type: research
Conclusion: Some dermoscopic patterns are observed consistently with certain diseases, and these can be used for their diagnosis, complementary to histopathological examination.
Source: Indian Journal of Dermatology - Category: Dermatology Authors: Source Type: research
This study included 89 paraffin-embedded blocks contain OLP (44 cases), CLP (45 cases) and NOM from the archive of Mashhad University of Medical Sciences, Mashhad, Iran. The expression of RORγt and IL-17 was evaluated by Real-time RT-PCR method. The result was compared to Leukocyte counts and the other hematological parameters of studied patients.RESULTS: The results of our study showed IL-17 and RORγt expression in OLP lesions were significantly higher than CLP and NOM groups (P = 0.001). Although we found high expression of RORγt and IL-17 in erosive OLP in compared to classic OLP lesion, but this incre...
Source: Cytokine - Category: Molecular Biology Authors: Source Type: research
by Phuc Thi-Duy Vo, Sun Shim Choi, Hae Ryoun Park, Ahreum Lee, Sung-Hee Jeong, Youngnim Choi Oral lichen planus (OLP) is one of the most prevalent oral mucosal diseases, but there is no cure for OLP yet. The aim of this study was to gain insights into the role of barrier dysfunction and infection in OLP pathogenesis through analysis of transcriptome datasets available in public databases. Two transcriptome datasets were downloaded from the Gene Expression Omnibus database and analyzed as whole and as partial sets after removing outliers. Differentially expressed genes (DEGs) upregulated in the dataset of OLP versus health...
Source: PLoS One - Category: Biomedical Science Authors: Source Type: research
This study aimed to assess the relationship and possible interactions between metallothioneins (MTs) and megalin (LRP-2) in different grades of oral squamous cell carcinoma (OSCC) and premalignant lesions of the oral mucosa (oral leukoplakia and oral lichen planus). The study included archived samples of 114 patients and control subjects. Protein expression was examined by immunohistochemistry and immunofluorescence, and staining quantification was performed by ImageJ software. Protein interaction in cancer tissue was tested and visualized by proximity ligation assay. Mann-Whitney and Kruskal-Wallis tests were used to dete...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Acta Derm Venereol. 2021 Sep 7. doi: 10.2340/00015555-3917. Online ahead of print.ABSTRACTNail dermoscopy (onychoscopy) is a valuable diagnostic tool for evaluating diseases in the nail apparatus. It is non-invasive, allowing clinicians to prioritize particular nails for biopsy. Thus, it can improve diagnostic accuracy and expedite treatment. Evaluating inflammatory nail disorders using onychoscopy is a relatively new approach to clinical assessment and has the potential to augment clinical care. This review highlights key dermoscopic features of major inflammatory nail disorders, including trachyonychia, nail psoriasis, n...
Source: Acta Derm Venereol A... - Category: Dermatology Authors: Source Type: research
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