In Vitro Testing of Sunscreens for Dermal Absorption: A Platform for Product Selection for Maximal Usage Clinical Trials
Sunscreen products contain UV-filters as active ingredients for the protection of skin against UV radiation. FDA issued a new proposed rule in 2019 (84.FR.6204) for sunscreens and identified the need for additional safety data for certain UV-filters including their dermal absorption data. Dermal absorption data reveals systemic exposure of UV-filters in humans, which can be obtained from clinical maximal usage trials. FDA guidance recommends conducting in vitro skin permeation tests (IVPT) to help select formulations for maximal usage clinical trials, as IVPT results may be indicative of in vivo absorption.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Yang Yang, Ann-Marie Ako-Adounvo, Jiang Wang, Jinhui Zhang, Daniel Willett, Huzeyfe Yilmaz, Maxwell Korang-Yeboah, Hao-jui Hsu, Jian Wang, Sergio G. Coelho, Steven A. Adah, Theresa M. Michele, Patrick J. Faustino, Celia N. Cruz, Sau Lee, Muhammad Ashraf Tags: Original Article Source Type: research