Cancers, Vol. 12, Pages 1090: Integrative Transcriptome Analyses of the Human Fallopian Tube: Fimbria and Ampulla —Site of Origin of Serous Carcinoma of the Ovary

Cancers, Vol. 12, Pages 1090: Integrative Transcriptome Analyses of the Human Fallopian Tube: Fimbria and Ampulla—Site of Origin of Serous Carcinoma of the Ovary Cancers doi: 10.3390/cancers12051090 Authors: Ramlogan Sowamber Omar Nelson Leah Dodds Victoria DeCastro Iru Paudel Anca Milea Michael Considine Leslie Cope Andre Pinto Matthew Schlumbrecht Brian Slomovitz Patricia A. Shaw Sophia H. L. George Epithelial ovarian cancer represents a group of heterogeneous diseases with high grade serous cancer (HGSC) representing the most common histotype. Molecular profiles of precancerous lesions found in the fallopian tube have implicated this tissue as the presumptive site of origin of HGSC. Precancerous lesions are primarily found in the distal fallopian tube (fimbria), near the ovary relative to the proximal tissue (ampulla), nearer to the uterus. The proximity of the fimbria to the ovary and the link between ovulation, through follicular fluid release, and ovarian cancer risk led us to examine transcriptional responses of fallopian tube epithelia (FTE) at the different anatomical sites of the human fallopian tube. Gene expression profiles of matched FTE from the fimbria and from premenopausal women resulted in differentially expressed genes (DEGs): CYYR1, SALL1, FOXP2, TAAR1, AKR1C2/C3/C4, NMBR, ME1 and GSTA2. These genes are part of the antioxidant, stem and inflammation pathways. Comparisons between the luteal phase (post-ovulation) to the fol...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research