Association with SERCA2a directs phospholamban trafficking to sarcoplasmic reticulum from a nuclear envelope pool

Phospholamban (PLB) stoichiometrically regulates the cardiac Ca2+ pump (SERCA2a) in the sarcoplasmic reticulum (SR); but in the nuclear envelope (NE) of cardiomyocytes (CMs), the PLB to SERCA2a molar ratio is higher, which highlights our poor understanding of how SR proteins distribute to their functional subcompartments. By tracking newly made PLB and SERCA2a in CMs, we will elucidate underlying cellular pathways responsible for their unique intracellular distributions.

Source: Journal of Molecular and Cellular Cardiology - April 26, 2020 Category: Cytology Authors: Wenbo He, Dayang Huang, Shuai Guo, Danning Wang, Jin Guo, Steven E. Cala, Zhenhui Chen Source Type: research