Diabetes mellitus exacerbates citrin deficiency via glucose toxicity.

CONCLUSION: Glucose is not toxic for citrin deficiency in normoglycemia because glucose uptake and metabolism by hepatocytes are limited in normoglycemia. However, glucose becomes toxic during persistent hyperglycemia and antidiabetic therapy is indispensable for CTLN2 patients with DM. PMID: 32335094 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32335094?dopt=Abstract

Source: Clin Med Res - April 22, 2020 Category: Research Authors: Watanabe Y, Numakura C, Tahara T, Fukui K, Torimura T, Hiromatsu Y, Tomotsune K, Yamakawa M, Hayasaka K Tags: Diabetes Res Clin Pract Source Type: research