Molecular subtypes of clear cell carcinoma of the endometrium: Opportunities for prognostic and predictive stratification.

CONCLUSION: CCC is a heterogeneous disease encompassing all four molecular subtypes and a wide range of clinical outcomes. Outcomes of patients with POLEmut, MMRd and p53abn CCC are not distinguishable from those of other patients with these respective subtypes of EC; p53wt CCC, however, differ from endometrioid p53wt EC in clinical, pathological, molecular features and outcomes. Thus, p53wt CCC of endometrium appear to be a distinct clinicopathological entity within the larger group of p53wt ECs.
PMID: 32331700 [PubMed - as supplied by publisher]

Source: Gynecologic Oncology - April 20, 2020 Category: Cancer & Oncology Authors: Kim SR, Cloutier BT, Leung S, Cochrane D, Britton H, Pina A, Storness-Bliss C, Farnell D, Huang L, Shum K, Lum A, Senz J, Lee CH, Gilks CB, Hoang L, McAlpine JN Tags: Gynecol Oncol Source Type: research