Academic Endocrinologist - Lebanon, New Hampshire, USA

Dartmouth-Hitchcock Clinic in Lebanon, NH and the Geisel School of Medicine at Dartmouth are searching for a BC/BE fellowship-trained endocrinologist. The ideal candidate is a general endocrinologist experienced in thyroid ultrasound and ultrasound guided fine needle aspiration who is interested in leading a thyroid ultrasound practice, as well as participating in the full complement of the Section’s clinical and educational responsibilities, including inpatient and outpatient consultation, and didactic/clinical supervision of medical students, residents, and fellows. 3-5 years of clinical experience is preferred, but not required. The Endocrinology Section at Dartmouth-Hitchcock Medical Center supports 2-3 fellows in endocrinology per year in a 2-3 year fellowship. The Section is a major participant in a well-integrated inpatient/outpatient tertiary care facility and oversees Tumor Boards in thyroid cancer and pituitary tumors. Opportunities for research are a possibility as well. Candidates must be eligible to be licensed by the State of New Hampshire. This position includes a faculty appointment at the Geisel School of Medicine at Dartmouth. Academic rank and compensation will be consistent with experience and medical center policies. There is currently no deadline set for this role. To apply, please send a cover letter and CV via email to:
Source: Society for Endocrinology - Category: Endocrinology Source Type: news

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Conclusions This review describes how leukocyte-heparanase can be a double-edged sword in tumor progression; it can enhance tumor immune surveillance and tumor cell clearance, but also promote tumor survival and growth. We also discuss the potential of using heparanase in leukocyte therapies against tumors, and the effects of heparanase inhibitors on tumor progression and immunity. We are just beginning to understand the influence of heparanase on a pro/anti-tumor immune response, and there are still many questions to answer. How do the pro/anti-tumorigenic effects of heparanase differ across different cancer types? Does...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Ivana Bjelobaba1,2, Marija M. Janjic1,2, Rafael Maso Prévide1, Daniel Abebe1, Marek Kucka1 and Stanko S. Stojilkovic1* 1Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health (NIH), Bethesda, MD, United States 2Institute for Biological Research Sinisa Stankovic, University of Belgrade, Belgrade, Serbia Cell-matrix interactions play important roles in pituitary development, physiology, and pathogenesis. In other tissues, a family of non-collagenous proteins, termed SIBLINGs, are known to contribute to cell-matrix interactions. Anterior pituitary gland...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
Rats affected by the MENX syndrome spontaneously develop multiple neuroendocrine tumors (NETs) including adrenal, pituitary and thyroid gland neoplasms. MENX was initially reported to be inherited as a recessive trait and affected rats were found to be homozygous for the predisposing Cdkn1b mutation encoding p27. We here report that heterozygous MENX-mutant rats (p27+/mut) develop the same spectrum of NETs seen in the homozygous (p27mut/mut) animals but with slower progression. Consequently, p27+/mut rats have a significantly shorter lifespan compared with their wild-type (p27+/+) littermates. In the tumors of p27+/mut rat...
Source: Endocrine-Related Cancer - Category: Endocrinology Authors: Tags: Research Source Type: research
AbstractPurposeAcromegaly is a disease associated with an increased risk for several kinds of neoplasms including colon and thyroid cancer. Although the association between acromegaly and pancreatic neoplasms has not been elucidated, it has recently been reported thatGNAS gene mutations were found in 58% of intraductal papillary mucinous neoplasms (IPMNs), which are representative pancreatic cystic lesions, suggesting a link between IPMNs and acromegaly. To assess the prevalence of pancreatic cystic lesions in patients with acromegaly, we performed a retrospective cross-sectional single institute study.MethodsThirty consec...
Source: Pituitary - Category: Endocrinology Source Type: research
Ever since I started an online community for treatment-resistant depression — depression and anxiety that don’t respond to psychotropic medications — I’ve been inundated with mail from desperate people who have tried 30 to 40 different kinds of antidepressants, and feel no relief. I repeatedly hear from family members of folks who have tried everything, and are not getting better. I sense the utter frustration and despair in their words, and it pains me. I, too, felt hopeless after trying countless medication combinations and sitting through years of psychotherapy sessions, only to continue my ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Alternative and Nutritional Supplements Depression Mental Health and Wellness Motivation and Inspiration Self-Help Treatment Alternative Medicine Bipolar Disorder homeopathy Immune System Mood Disorder Omega-3 fatty acid Sleep st Source Type: blogs
Conclusions 18F-PET/CT imaging is a valuable approach to differential diagnosis of pituitary lesions.
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: MTA II: Neurology Posters Source Type: research
We report the case of a 40-year-old male without significant family history of endocrine disease who was found to have primary hyperparathyroidism, a pituitary tumor causing acromegaly, thyroid cancer, renal cell carcinoma, and pancreatic cysts. We posit that this represents a new version of MEN-4. While renal tumors (angiomyolipoma) have been reported as part of the MEN-4 phenotype, to our knowledge, this is the first case reported of the association of MEN-1 and/or MEN-4 phenotype with this unique constellation of tumors, including renal cell carcinoma. Interestingly, this patient tested negative (DNA sequencing/deletion...
Source: Cardiorenal Medicine - Category: Urology & Nephrology Source Type: research
Conclusions No significant differences between survivin and its splice variants ∆Ex3 and 2β expression in pituitary tumors and in normal pituitary glands as well as in invasive and in non-invasive tumors were found, suggesting that survivin does not play a significant role in pituitary tumorigenesis.
Source: Pituitary - Category: Endocrinology Source Type: research
Although not detectable in normal breast tissue, the sodium iodide symporter (NIS) has been found to be expressed in 70-80% of breast cancers. However, the majority of NIS is intracellular, leaving only 20-30% functional at the plasma membrane. Whilst radioiodine therapy has been proposed as a potential treatment for breast cancer, effective therapy would require increased levels of membranous NIS localisation in tumours. Previous work revealed that overexpression of pituitary tumor transforming gene binding factor (PBF) in thyroid cells leads to the redistribution of NIS from the plasma membrane into intracellular vesicle...
Source: Cancer Research - Category: Cancer & Oncology Authors: Tags: Poster Session Abstracts Source Type: research
Conclusions: The elevated incidence of DTC in patients with TSHoma suggests a possible role of TSH hypersecretion in the development of thyroid tumors. A formal high-resolution ultrasound of the thyroid is recommended in patients diagnosed with a TSHoma, especially if a long history of the pituitary tumor is suspected. Moreover, suspicion about the presence of TSHoma should be raised by the lack of suppression of TSH levels despite adequate doses of levo-thyroxine after thyroidectomy for DTC. PMID: 25647054 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
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