U-M tinnitus discovery opens door to possible new treatment avenues

(University of Michigan Health System) For tens of millions of Americans, a diagnosis of tinnitus means there's no such thing as the sound of silence. Now, new scientific findings may help explain what is going on inside these unquiet ears and brains.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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Atypical facial neuralgias are a rare condition, that present predominantly in the female population, with an annual incidence of 3-4 cases every 100 000 people. The trigeminal nerve root is mostly affected, and not commonly combined with autonomic symptoms. We are presenting a 59 years old, female patient, with significant medical history for anxiety, depression and autoimmune liver disease, on long term steroid treatment. She suddenly started complaining of severe periodic right facial pain about 15 years ago, after an sneezing episode, described as stabbing in quality and triggered by minor stimulus; also accompanied wi...
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research
This study summarizes new tinnitus data from the Canadian Health Measures Survey (CHMS). DATA AND METHODS: Data were collected for individuals aged 19 to 79 years (n=6,571) from 2012 through 2015 as part of the CHMS. Tinnitus is described as "the presence of hissing, buzzing, ringing, rushing or roaring sounds in your ears when there is no other sound around you." Bothersome tinnitus refers to tinnitus affecting sleep, concentration or mood. Factors associated with tinnitus were examined using bivariate and logistic regression analyses. RESULTS: An estimated 37% of adult Canadians (9.2 million) had experi...
Source: Health Reports - Category: International Medicine & Public Health Tags: Health Rep Source Type: research
ConclusionsThis study revealed a deficit in sensory memory and change detection processing in decompensated tinnitus subjects. This causes persistent prediction errors; tinnitus signal is consistently detected as a new signal and activates the brain salience network and consequently prevents habituation to tinnitus. Mismatch negativity is proposed as an index for monitoring tinnitus rehabilitation.
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Objective: To investigate the clinical characteristics, etiology, treatment outcomes, and prognostic factors of sudden sensorineural hearing loss (SSNHL) in children to guide the clinical diagnosis and treatment of SSNHL in the pediatric population. Study Design: Retrospective case review. Setting: Tertiary referral center. Patients: Patients diagnosed with SSNHL from November 2011 to December 2017 with relatively complete clinical data. Intervention: Diagnosis and systemic treatment of SSNHL. Main Outcome Measures: Patients’ clinical characteristics, etiology, laboratory tests, imaging, pure-tone au...
Source: Otology and Neurotology - Category: ENT & OMF Tags: SENSORINEURAL HEARING LOSS AND TINNITUS Source Type: research
Conclusions: Surgical sealing of both windows in suspected barotraumatic PLF is an effective treatment to improve hearing and subjective dizziness.
Source: Otology and Neurotology - Category: ENT & OMF Tags: SENSORINEURAL HEARING LOSS AND TINNITUS Source Type: research
Objectives: To determine whether long term (>48 months) symptomatic vertigo control is sustained in patients with Menière's disease from a previous comparative trial of intratympanic methylprednisolone versus gentamicin, and if the two treatments remain nonsignificantly different at long-term follow-up. Study Design: Mail survey recording vertigo frequency in the previous one and six months, further intratympanic treatment received, and validated symptom questionnaires. Setting: Outpatient hospital clinic setting. Patients: Adult patients with definite unilateral refractory Menière's disease, wh...
Source: Otology and Neurotology - Category: ENT & OMF Tags: VESTIBULAR DISORDERS Source Type: research
This contribution focuses on the relationship between stress and tinnitus. While the causal and directional pathways between these constructs continue to remain unclear, this paper uses an allostasis-based framework to discuss associations between physiological stress responses, individuals’ idiosyncratic experiences of the tinnitus percept, and psychological treatment approaches.
Conclusions: Tinnitus was associated with a wide range of conditions, in particular disorders of the ear.
Source: Otology and Neurotology - Category: ENT & OMF Tags: AUDIOLOGY Source Type: research
Publication date: Available online 18 March 2019Source: American Journal of OtolaryngologyAuthor(s): Daniel C. O'Brien, Aaron D. Robinson, Nancy Wang, Rodney DiazAbstractObjectiveTo assess the efficacy of transdermal lidocaine as a treatment for chronic subjective tinnitus as measured by the Tinnitus Functional Index (TFI).Study designPilot, prospective efficacy trial.SettingTertiary care hospital.PatientsMen and women, over the age of 18 with chronic subjective tinnitus for>6 months.InterventionDaily application of commercially available transdermal lidocaine patch.Outcome measureChange in the TFI.ResultsThe average ...
Source: American Journal of Otolaryngology - Category: Endocrinology Source Type: research
Publication date: Available online 16 March 2019Source: NeuroscienceAuthor(s): Hannah Brotherton, Charlotte Turtle, Christopher J. Plack, Kevin J. Munro, Roland SchaetteAbstractThe occurrence of tinnitus is associated with hearing loss and neuroplastic changes in the brain, but disentangling correlation and causation has remained difficult in both human and animal studies. Here we use earplugs to cause a period of monaural deprivation to induce a temporary, fully reversible tinnitus sensation, to test whether differences in subcortical changes in neural response gain, as reflected through changes in acoustic reflex thresho...
Source: Neuroscience - Category: Neuroscience Source Type: research
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