Combined PIKFYVE and p38 MAP Kinase Inhibition for Treating Cancer

Cancer cells can upregulate autophagy – recycling of components – as a response to chemotherapy. Investigators in Dr. Melvin DePamphilis’ laboratory at the Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) have shown that PIKFYVE inhibitors and p38 MAP kinase inhibitors work synergistically in vitro to kill cancer cells (e.g., colon adenocarcinomas, non-small cell lung carcinoma, glioblastoma, breast adenocarcinoma and osteosarcoma), but are not toxic to normal cells.  Cancer cells with a BRAF mutation are especially dependent on autophagy. Treatment of cancer cells containing the BRAF mutation with PIKFYVE inhibitors can increase the efficacy of chemotherapy. Preliminary proof of concept in vivo studies indicate that the compounds work synergistically to inhibit tumor growth in a xenograft model. NICHD seeks licenses and/or co-development partners for methods of treating cancer by administering PIKFYVE inhibitors and P38 MAP kinase inhibitors.IC: NICHDNIH Ref. No.: E-138-2019Advantages: The methods of treating cancer by administering PIKFYVE and p38 MAP kinase inhibitors are selective for cancer cells and are not toxic to normal cells  Potentially promising safety/toxicity profile for human useApplications: Treatment of a wide range of cancers, including – but not limited to – colon adenocarcinomas, non-small cell lung carcinoma, glioblastoma, breast adenocarcinoma and oste...
Source: NIH OTT Licensing Opportunities - Category: Research Authors: Source Type: research

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Publication date: Available online 12 July 2020Source: Pharmacology Biochemistry and BehaviorAuthor(s): A. Biggerstaff, B. Kivell, J.L. Smith, Md Y. Mian, L.K. Golani, F. Rashid, D. Sharmin, D.E. Knutson, R. Cerne, J.M. Cook, J.M. Witkin
Source: Pharmacology Biochemistry and Behavior - Category: Biochemistry Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/C9NJ05989J, PaperK S Sharma, A. K. Dubey, Arunkumar S, Koijam, Chandan Kumar, Anand Ballal, Sudip Mukherjee, Prasad P Phadnis, R K Vatsa Abstract Water soluble Pt(IV) prodrug of cisplatin was synthesized by oxidation of cisplatin followed by treatment with succinic anhydride to achieve easily reducible ester linkage at axial positions which was... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
New J. Chem., 2020, Accepted Manuscript DOI: 10.1039/D0NJ02844D, PaperMuhammad Khattab, Ahmed A. Al-Karmalawy Preclinical and clinical studies on Mebendazole revealed its potential as anticancer agent. We therefore aimed to investigate its binding interactions with one of the most important cancer targets (Tubulin protein)... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - New J. Chem. latest articles - Category: Chemistry Authors: Source Type: research
Mice that experienced heart attacks underwent a large-scale shift in their immune systems that allowed cancer to flourish, perhaps explaining the observation in patients.
Source: The Scientist - Category: Science Tags: News & Opinion Source Type: news
Conclusion: In this cohort of patients with esophageal cancer admitted to intensive care units with acute illness, the in-hospital mortality rate was very high. The requirement for invasive mechanical ventilation and metastatic disease were independent prognostic factors and should be considered in discussions about the short-term outcomes of these patients.
Source: Revista Brasileira de Terapia Intensiva - Category: Intensive Care Source Type: research
Loss of chromosome Y (LOY) is a mosaic aneuploidy that can be detected mainly in blood samples of male individuals. Usually, LOY occurrence increases with chronological age in healthy men. Moreover, recently LOY has been reported in association with several diseases, such as cancer, where its frequency is even higher. The Y chromosome is one of the shortest chromosomes of the human karyotype, and it is crucial for correct male development. This chromosome has functions beyond the male reproductive system, and loss of its genes or even LOY can have consequences for the male body that are yet to be elucidated. Analyses of th...
Source: Cytogenetic and Genome Research - Category: Genetics & Stem Cells Source Type: research
ConclusionsAortoiliac calcification may be considered a risk factor for grade C AL after rectal cancer surgery.
Source: Techniques in Coloproctology - Category: Surgery Source Type: research
Source: Techniques in Coloproctology - Category: Surgery Source Type: research
ConclusionsTpAPE seems to be feasible with acceptable perioperative morbidity and a relatively low rate of perineal wound dehiscence, while histopathological outcomes remain suboptimal. Additional evaluation of the viability of this technique is needed in the form of a prospective trial with standardization of the procedure, indication, audit of outcomes and performed by surgeons with vast experience in transanal total mesorectal excision.
Source: Techniques in Coloproctology - Category: Surgery Source Type: research
Li Liu, Jiajing Lin and Hongying He* Department of Obstetrics and Gynecology, Liuzhou Worker’s Hospital, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, China Background and Objective: Endometrial cancer (EC) is a common gynecological malignancy worldwide. Despite advances in the development of strategies for treating EC, prognosis of the disease remains unsatisfactory, especially for advanced EC. The aim of this study was to identify novel genes that can be used as potential biomarkers for identifying the prognosis of EC and to construct a novel risk stratification using these genes. Me...
Source: Frontiers in Genetics - Category: Genetics & Stem Cells Source Type: research
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