Regarding “Hormone Replacement Therapy Prescription After Premature Surgical Menopause”
With a great deal of interest we read the article entitled ” Hormone Replacement Therapy Prescription After Premature Surgical Menopause” by Garg et al . They analysed a cohort of Sixty-three of which 20.6% had operation for gynaecological cancer including cervical cancer (1.6%), uterine cancer (14.2%), and ovarian cancer (4.8%).Other indications wer e BRCA carrier (17.4%), breast cancer (9.5%), Lynch syndrome (4.8%). Women treated for gynaecological or breast cancer or had BRCA gene mutations were less likely to use HRT.
Publication date: Available online 15 July 2020Source: Progress in Lipid ResearchAuthor(s): Wenjie Chen, Ewa M. Goldys, Wei Deng
Publication date: Available online 15 July 2020Source: The Annals of Thoracic SurgeryAuthor(s): Kristen E. Rhodin, Vignesh Raman, Oliver K. Jawitz, Soraya L. Voigt, Norma E. Farrow, David H. Harpole, Betty C. Tong, Thomas A. D’Amico
Authors: Zhou Y, Chi Y, Bhandari A, Xia E, Thakur PC, Qu J, Wang O, Zhang X Abstract BACKGROUND: Placental-Cadherin (CDH3), a cell adhesion molecule, is associated with the function of cells to bind with other cells and the extracellular matrix (ECM). CDH3 is highly expressed in many malignancies, and has been proved it could be a serum marker to monitor colorectal cancer, but the CDH3 expression levels in thyroid cancer is still not clear. In this article, we will illuminate the correlation between CDHs expression and thyroid cancer. MATERIALS AND METHODS: We analyzed the level of CDH3 expression in 60 pair of...
This study provides a theoretical basis for the improvement of QOL in BC patients. PMID: 32655829 [PubMed]
In this study, we investigated whether leptin, adiponectin, and their receptors have an impact on bladder cancer outgrowth and the mechanisms involved. We performed immunohistochemistry for leptin, leptin receptor (Ob-R), adiponectin, and adiponectin receptors (AdipoR1, AdipoR2) in bladder cancer tissue microarrays. Wound healing assay and western blot were then performed in human bladder cancer lines. The positive rates (0 vs 1+/2+/3+) of Ob-R (P=0.004), adiponectin (P
CONCLUSIONS: The result revealed RTL4 is closely related to the occurrence and development of PTC. RTL4 may participate in the HOTAIR-miR-206-ZCCHC16 ceRNA regulatory network and be regulated and play a role in the ceRNA regulatory network. It may be used as a target or indicator for the treatment and prognosis of PTC. PMID: 32655827 [PubMed]
Authors: Dai T, Deng M, Ye L, Liu R, Lin G, Chen X, Li H, Liu W, Yang Y, Chen G, Wang G Abstract The gamma-glutamyl transpeptidase to platelet ratio (GPR) has been reported as a non-invasive parameter for evaluating hepatic fibrosis and cirrhosis. However, only a few of studies investigated the relationship between GPR and liver cancer. Here, we sought to clarify the prognostic value of GPR as well as its combination with fibrinogen in patients with HBV-related hepatocellular carcinoma (HCC). We performed a retrospective study using data collected from 302 HCC patients, and evaluated the association between GPR, fi...
In conclusion, we demonstrated a lncRNA KRT16P2/miR-1294/EGFR axis that regulates LSCC cell proliferation, invasion, and migration. The clinical application of this axis needs further in vivo and clinical investigation. PMID: 32655821 [PubMed]
In conclusion, CTC EMT is significantly related to Ki67 expression, and is a risk factor of NSCLC. PMID: 32655819 [PubMed]
In this study, the expression of PVT1 in several ovarian cancer cell lines was analyzed by qRT-PCR. The effect of PVT1 on malignant behaviors, including cell proliferation, migration and invasion, was analyzed. The posttranscriptional regulation of FOXM1 by PVT1 was analyzed by western blotting. The results illustrated that PVT1 acted as a sponge and bound miR-370 on two binding sites. The expression of PVT1 positively regulated malignant behaviors in ovarian cancer cells, including cell proliferation, migration and invasion, which could be reversed by the introduction of miR-370 mimics. Sponged miR-370 failed to posttrans...